I'm getting occasional hangs (spinning pizza of death) on ST2 2.0.1 (Mac OS X 10.6.8, Mac Pro). I don't know how to reproduce the problem. It seems like it happens during extended editing sessions, but I've also had ST2 hang when I re-open a project.
When I use the "Force Quit Application" dialog to get out, I'm offered the chance to send a report to Apple. So, I grabbed the text and enclosed it (as st2_hang_report).