I use Windows 7 at work where our home directory and app data is stored on a network share (so %APPDATA% resolves to \\<server-name>\<username>\application_data).
ST2 (I've tried both 2181 and currently 2200) often doesn't load correctly. Either the theme doesn't look right or packages don't get loaded. In the console the "loaded x snippets" can vary from anywhere between 400 to 900 and occasionally the theme file doesn't get found. I'm assuming this is something to do with the files being on a network drive as I don't have the same issues at home.
Is there anything that can be done to make this more reliable? Happy to provide further details/diagnostics if needed.