I have experimented running Sublime Text under Virtual Box (on a Mac OSX host). Everything is fine using the --opengl switch or the "renderer opengl" option. It's slow largely because Virtual Box's support for OpenGL is still experimental, but it works.
Only one quirk; when the cursor is in the text area, it becomes almost invisible. It's black and thin, and so disappears over a dark background. I do not recall having the same issue when running natively (using Bootcamp on my Mac). Does this make sense?