This is kinda old and IMHO one huge feature that would help users a lot
I also have some packages/settings that I want to override based on which project I'm working on.. if that was possible based on project or at least based on workspace, it would already help a lot.
Does anyone knows if any package can change user defined configuration? one could create a package that reads the project file and disable/enable the packages.
I know that Package Control can do this already.. so it seems feasible, I'm going to send a request to Will Bond on that as I think it makes perfect sense for his package control!
In the mean time, if anyone wants to give it a shot on this, it would be a huge success