20100425 is out now, fixing a couple of minor issues, as well as improving startup time. It also features a newer version of Python: 2.6.5, as opposed to 2.5. This could break some plugins, although things to appear to be working fine in the testing I’ve done.
Because of the upgrade in Python versions, it’s best if you uninstall Sublime Text before installing this beta: otherwise you’ll be left with a python25.dll and python25.zip lying around unnecessarily.