In both ST2/3, I have a weird problem: all of the set_layout keybindings for rows/grid work, and the bindings for 3 columns and 4 columns, but the bindings for Single (super-alt-1) and 2 column (super-alt-2) do not. The menu items work, but not the keys. I have not been able to locate any OS-level keybindings that would be interfering with this feature. (Mac OS X 10.8.)
Has anybody else experienced this (particularly Mac)?